--- title: "AmaChol®: new scientific evidence on the potential of Amaranthus caudatus extract" description: "Discover new research on AmaChol®: composition, in vitro studies and preliminary human observations on Amaranthus caudatus extract." image: https://blog.ecsa-chemicals.ch/hubfs/amachol-amaranthus-caudatus.jpg --- ### Select your language [Deutsch](https://blog.ecsa-chemicals.ch/de/amachol-neue-wissenschaftliche-erkenntnisse-zum-potenzial-von-amaranthus-caudatus-extrakt)  |  [Français](https://blog.ecsa-chemicals.ch/fr/amachol-nouvelles-données-scientifiques-sur-le-potentiel-de-lextrait-damaranthus-caudatus)  |  [Italiano](https://blog.ecsa-chemicals.ch/it/amachol-nuove-evidenze-scientifiche-sul-potenziale-dellestratto-di-amaranthus-caudatus) [![ecsa chemicals](https://blog.ecsa-chemicals.ch/hubfs/ECSA_Chemicals_April2025/Images/logo.svg) ![ecsa chemicals](https://blog.ecsa-chemicals.ch/hubfs/ECSA_Chemicals_April2025/Images/logo-sticky.svg)](https://ecsa-chemicals.ch/) - [Industrial Chemicals](https://ecsa-chemicals.ch/en/industrial-chemicals/) - [Pharma & Nutrition](https://ecsa-chemicals.ch/en/pharma-nutrition/) - [Flavours & Fragrances](https://ecsa-chemicals.ch/en/flavours-fragrances/) - [Cosmetics & Detergents](https://ecsa-chemicals.ch/en/cosmetics-detergents/) - [Content Hub](https://blog-chemicals.ecsa.ch/en/ecsa-chemicals) - [About us](https://ecsa-chemicals.ch/en/about-us/) En - En - Products - [Industrial Chemicals](https://ecsa-chemicals.ch/en/industrial-chemicals/) - [Pharma & Nutrition](https://ecsa-chemicals.ch/en/pharma-nutrition/) - [Flavours & Fragrances](https://ecsa-chemicals.ch/en/flavours-fragrances/) - [Cosmetics & Detergents](https://ecsa-chemicals.ch/en/cosmetics-detergents/) - [Content Hub](https://blog-chemicals.ecsa.ch/en/ecsa-chemicals) - About us - [ECSA world](https://ecsa-chemicals.ch/en/about-us/the-ecsa-world/) - [Certifications & Quality](https://ecsa-chemicals.ch/en/about-us/quality-and-certifications/) - [Security & environment](https://ecsa-chemicals.ch/en/about-us/safety-and-the-environment/) - [Infrastuctures logistics & services](https://ecsa-chemicals.ch/en/about-us/infrastructure-logistics-and-services/) - [Career](https://ecsa-chemicals.ch/en/about-us/career/) - [We Are ECSA](https://ecsa-chemicals.ch/en/about-us/we-are-ecsa/) - [Catalogs](https://ecsa-chemicals.ch/en/catalogues/) Follow us This is a search field with an auto-suggest feature attached. Search - There are no suggestions because the search field is empty. # AmaChol®: new scientific evidence on the potential of Amaranthus caudatus extract - [Home](https://ecsa-chemicals.ch/en/) - [Content Hub - Ecsa chemicals](https://blog.ecsa-chemicals.ch/en) - AmaChol®: new scientific evidence on the potential of Amaranthus caudatus extract 26 October 2026 Scientific research continues to explore the potential of plant-based ingredients in the nutraceutical sector, with particular attention to their composition, biological mechanisms and potential applications in innovative formulations. Within this context, **AmaChol®** is an extract derived from *Amaranthus caudatus L.* seeds, developed by **NatIng Italia** and distributed in Switzerland by **ECSA Chemicals – Pharma & Nutrition**. On 12 January 2026, the scientific journal *Frontiers in Nutrition* published the study *“Preliminary evaluation of an extract of Amaranthus caudatus as a novel nutraceutical: effects on cholesterol and glucose absorption”*, focusing on the characterisation of the extract and the preliminary evaluation of its biological activities. ## AmaChol®: a botanical ingredient for nutraceutical research AmaChol® is a dry extract obtained from *Amaranthus caudatus L.* seeds through an aqueous extraction process. According to the manufacturer's technical data sheet, the ingredient has the following characteristics: - **Botanical name:** *Amaranthus caudatus L.* - **Plant part used:** seeds - **Extraction solvent:** water - **Drug-extract ratio (DER):** 4:1 - **Country of manufacture:** Italy - **Excipients:** none - **Characteristics:** gluten-free and suitable for vegan formulations These characteristics make AmaChol® an ingredient of interest for the development of plant-based nutraceutical formulations. ## A new scientific publication The study published in *Frontiers in Nutrition* investigated AmaChol® through an approach combining metabolomic analyses, in vitro testing and preliminary observations in humans. Metabolomic characterisation enabled the annotation of numerous compounds belonging to different classes, including flavonoids, isoflavonoids, triterpenoids, fatty acids and phenolic compounds. The researchers subsequently investigated several biological processes related to carbohydrate digestion, intestinal glucose and cholesterol transport, and antioxidant activity. ### Inhibition of digestive enzymes In vitro tests demonstrated inhibitory activity against two enzymes involved in carbohydrate digestion: - **α-amylase:** responsible for the breakdown of starch. - **α-glucosidase:** involved in the release of glucose from carbohydrates. These results help describe the extract's potential mechanisms of action at intestinal level, which require further confirmation through controlled clinical studies. ### Intestinal glucose and cholesterol transport Using a three-dimensional model of human intestinal epithelium, the researchers observed reduced glucose transport in the presence of the extract compared with experimental controls. A reduction in the absorption of a fluorescent cholesterol analogue was also observed in the same model. **Scientific note:** these findings relate to experimental in vitro conditions and must not be interpreted as clinically demonstrated reductions in blood glucose or cholesterol levels in humans. ### Antioxidant activity Laboratory tests also demonstrated antioxidant activity of the extract, evaluated using a colorimetric assay based on ABTS oxidation. These observations contribute to a broader understanding of AmaChol®'s biological profile. ## Preliminary observations in humans The publication also reports an observational study conducted over three months in individuals with impaired glycaemic control. Of the 60 participants initially enrolled, data were available for 37 participants at the end of the observation period. The results showed statistically significant changes in certain parameters, including glycated haemoglobin (HbA1c), postprandial blood glucose and body mass index (BMI). Mean reductions in total and LDL cholesterol were also observed, although these changes did not reach statistical significance. **Study limitations:** the study was preliminary and did not include a parallel control group. Consequently, the observed changes cannot be attributed with certainty to consumption of the extract. Further randomised controlled clinical trials will be needed to confirm its efficacy and safety. ## Research and innovation in nutraceutical ingredients This publication provides a further contribution to the scientific characterisation of AmaChol® and to the exploration of botanical extracts for nutraceutical applications. The combination of metabolomic characterisation, experimental testing and human observations provides a foundation for further research. Through its collaboration with NatIng Italia, **ECSA Chemicals – Pharma & Nutrition** makes AmaChol® and its supporting technical and scientific documentation available to the Swiss market. ## Would you like to learn more about AmaChol®? Our Pharma & Nutrition team is available to provide technical information, product documentation and support in evaluating the ingredient for new formulations. [CONTACT OUR TEAM](mailto:pharma.nutrition@ecsa.ch?subject=AmaChol%20product%20enquiry) **Scientific reference** Mattiello A. et al. (2026). *Preliminary evaluation of an extract of Amaranthus caudatus as a novel nutraceutical: effects on cholesterol and glucose absorption.* Frontiers in Nutrition, 12:1740097. DOI: [10.3389/fnut.2025.1740097](https://doi.org/10.3389/fnut.2025.1740097) The findings presented are preliminary and do not constitute proof of clinical efficacy or authorisation to make health claims. --- #### Share: - [Follow us on Facebook](http://www.facebook.com/share.php?u=https://blog.ecsa-chemicals.ch/en/amachol-new-scientific-evidence-on-the-potential-of-amaranthus-caudatus-extract) - [Follow us on Twitter](https://twitter.com/intent/tweet?url=https://blog.ecsa-chemicals.ch/en/amachol-new-scientific-evidence-on-the-potential-of-amaranthus-caudatus-extract&text=AmaChol®:%20new%20scientific%20evidence%20on%20the%20potential%20of%20Amaranthus%20caudatus%20extract) - [Follow us on Linkedin](http://www.linkedin.com/shareArticle?mini=true&url=https://blog.ecsa-chemicals.ch/en/amachol-new-scientific-evidence-on-the-potential-of-amaranthus-caudatus-extract) - [Follow us on Pinterest](http://pinterest.com/pin/create/button/?url=https://blog.ecsa-chemicals.ch/en/amachol-new-scientific-evidence-on-the-potential-of-amaranthus-caudatus-extract&text=AmaChol®:%20new%20scientific%20evidence%20on%20the%20potential%20of%20Amaranthus%20caudatus%20extractdescription=Scientific%20research%20continues%20to%20explore%20the%20potential%20of%20plant-based%20ingredients%20in%20the%20nutraceutical%20sector,%20with%20particular%20attention%20to%20their%20composition,[...]&media=https://27166650.fs1.hubspotusercontent-eu1.net/hubfs/27166650/amachol-amaranthus-caudatus.jpg) #### [New partnership between ECSA Chemicals and CP ESSENZE Previous post](https://blog.ecsa-chemicals.ch/en/new-partnership-between-ecsa-chemicals-and-cp-essenze) ## Stay connected ### Receive the latest information and news from the chemistry world [![ecsa chemicals](https://blog.ecsa-chemicals.ch/hubfs/ECSA_Chemicals_April2025/Images/logo.svg "ecsa chemicals")](https://ecsa-chemicals.ch/) Social Associations and partners - [RSPO](https://www.rspo.org/) - [AssICC](https://www.assicconline.it/) - [Scienceindustries](https://www.scienceindustries.ch/) - [FECC](https://www.fecc.org/) - [Sedex](https://www.sedex.com/) - [IFEAT](https://ifeat.org/) - [SEPAWA](https://www.sepawa.com/) - [Bio Suisse](https://www.bio-suisse.ch/) - [World Chemical Distributor Directory](https://chemical-distributors.com/) - [EFEO](https://www.efeo.eu/) - [Cosmetica Italia](https://www.cosmeticaitalia.it/) - [Bioagricert](https://www.bioagricert.org/) - [Farma industria](https://www.farmaindustriaticino.ch/) - [Carlo Erba Reagents](https://ecsa-chemicals.ch/en/carlo-erba-reagents/) - [Contact us](https://ecsa-chemicals.ch/en/contact/) - [Catalogs](https://ecsa-chemicals.ch/en/catalogues/) - [Suppliers](https://ecsa-chemicals.ch/en/suppliers/) - [Career](https://ecsa-chemicals.ch/en/about-us/career/) - [We Are ECSA](https://ecsa-chemicals.ch/en/about-us/we-are-ecsa/) 2026 ECSA Group. All Rights Reserved - [Privacy policy](https://ecsa-chemicals.ch/en/privacy-policy/) - [Cookie Policy](https://ecsa-chemicals.ch/en/service-pages/cookie-policy/) - [ECSA Chemicals AG general sales and supply conditions](https://ecsa-chemicals.ch/en/service-pages/ecsa-chemicals-ag-terms-and-conditions-of-sale/) - [ECSA Italia srl general sales and supply conditions](https://ecsa-chemicals.ch/en/service-pages/general-conditions-of-sale-of-ecsa-italia-srl/) Site protected by reCAPTCHA. Google [Privacy Policy](https://policies.google.com/privacy) and [Terms of Service](https://policies.google.com/terms). ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "author" : { "@type" : "Person", "name" : "Anna Vanzini", "url" : "https://blog.ecsa-chemicals.ch/en/author/anna-vanzini" }, "dateModified" : "2026-10-26T08:26:51.620Z", "datePublished" : "2026-10-26T08:24:36.000Z", "headline" : "AmaChol®: new scientific evidence on the potential of Amaranthus caudatus extract", "image" : [ "https://blog.ecsa-chemicals.ch/hubfs/amachol-amaranthus-caudatus.jpg" ], "mainEntityOfPage" : { "@id" : "https://blog.ecsa-chemicals.ch/en/amachol-new-scientific-evidence-on-the-potential-of-amaranthus-caudatus-extract", "@type" : "WebPage" }, "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://blog.ecsa-chemicals.ch/hubfs/540x120.png" }, "name" : "ECSA Chemicals AG" } } ```